List of Speakers

 

National Lecturer

Hue Sun Chan

Hue Sun Chan

University of Toronto

Protein folding and interactions are physico-chemical processes. Dr. Chan’s group aims to elucidate their underlying energetics. To this end, a main emphasis of our effort is to develop proteinlike heteropolymer models with coarse-grained interactions and simplified representations of chain geometries. The rationale of these approaches is to capture the essential physics and at the same time allow for a broad coverage of the protein conformational space – and also a broad coverage of the sequence space for evolutionary studies – that is not readily achievable currently in higher-resolution models. Molecular dynamics simulations using common atomic forcefields and explicit water models are used in our work as well, especially for deciphering subtle properties of solvent-mediated interactions. Various combinations of coarse-grained and atomic methods are being used to gain physical insights into general principles of folding, protein interactions, and evolution. The topics they address include folding cooperativity, origin of enthalpic and volumetric folding barriers, nonnative effects in folding, formation of functional and disease-causing dynamic, “fuzzy” complexes involving intrinsically disordered proteins, and conformational switching in protein evolution. Some of these efforts, including investigations into the mathematical basis of the unknotting, decatenating, and supercoil simplifying actions of type-2 topoisomerases, are highlighted in Prof. Chan’s website.

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Keynote Speakers

Samuel T. Hess

Samuel T. Hess

University of Maine

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Edward Lemke

Edward Lemke

Johannes Gutenberg University

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Tanja Mittag

Tanja Mittag

St. Jude Children's Research Hospital

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Johan Paulsson

Johan Paulsson

Harvard University

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InvitedĀ Speakers

Jingyi Fei

Jingyi Fei

University of Chicago

Ilya Finkelstein

Ilya Finkelstein

University of Texas, Austin

Julie Forman-Kay

Julie Forman-Kay

University of Toronto/Sick Kids

Voula Kanelis

Voula Kanelis

University of Toronto Mississauga

Sabrina Leslie

Sabrina Leslie

McGill University

Matthew Lew

Matthew Lew

Washington University in St. Louis

Lisa Manning

Lisa Manning

Syracuse University

Scott Prosser

Scott Prosser

University of Toronto Mississauga

Andrew Pelling

Andrew Pelling

University of Ottawa

Regis Pomes

Regis Pomes

University of Toronto/Sick Kids

Jon Rocheleau

Jon Rocheleau

University of Toronto

Andrew Rutenberg

Andrew Rutenberg

Dalhousie University

Gary Slater

Gary Slater

University of Ottawa

Jenifer Thewalt

Jenifer Thewalt

Simon Fraser University

Danielle Tokarz

Danielle Tokarz

Saint Mary's University

Erdal Toprak

Erdal Toprak

UT Southwestern

Paul Wiseman

Paul Wiseman

McGill University

Michael Woodside

Michael Woodside

University of Alberta

Christopher Yip

Christopher Yip

University of Toronto

Anton Zilman

Anton Zilman

University of Toronto