Claudiu Gradinaru

Claudiu Gradinaru
UofT Mississauga (ON)

The Gradinaru biophysics research laboratory employs advanced laser and detection technology to measure the structural heterogeneity of biological molecules and to capture the dynamics of molecular conformations and interactions at the single-molecule level. Single-molecule fluorescence (SMF) techniques are now widely used in life sciences, including applications focused on studying protein and RNA folding, molecular motors, enzymatic activity, DNA replication, and the dynamics of ion channels and membrane receptors. Single-molecule experimental approaches have the unique capability to observe and quantify the disorder and complexity of biological systems and can provide crucial feedback for theory and for molecular dynamics simulations.